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- Title
The MicroRNAs in the Pathophysiology of Osteoporosis.
- Authors
Trojniak, Julia; Sendera, Anna; Banaś-Ząbczyk, Agnieszka; Kopańska, Marta
- Abstract
Globally, osteoporosis is the most common systemic skeletal disease. There are many factors that influence osteoporosis' development and progression. During the pathogenesis of this disease, bone turnover is imbalanced between resorption and the formation of bone tissue. A growing interest has been devoted to the role that microRNA (miRNA) plays in osteoporosis regulation. A microRNA (miRNA) is a group of small single-stranded RNA molecules involved in regulating gene expression in eukaryotic organisms. As microRNAs (miRNAs) are key regulators of gene expression and can modulate processes related to bone metabolism, they have become increasingly important for studying osteoporosis pathogenesis. The available research suggests that miRNAs play an important role in regulating processes associated with bone metabolism, especially by influencing bone resorption and synthesis. Furthermore, microRNAs can also serve as potential therapeutic targets for osteoporosis, besides being a rapid and specific biomarker.
- Subjects
OSTEOPOROSIS; NON-coding RNA; PATHOLOGICAL physiology; MICRORNA; BONE remodeling; BONE resorption
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 11, p6240
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25116240