We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nicotinic Receptors in Human Chromaffin Cells: Characterization, Functional and Physical Interactions between Subtypes and Regulation.
- Authors
Jiménez-Pompa, Amanda; Albillos, Almudena
- Abstract
This review summarizes our research on nicotinic acetylcholine receptors in human chromaffin cells. Limited research has been conducted in this field on human tissue, primarily due to the difficulties associated with obtaining human cells. Receptor subtypes were characterized here using molecular biology and electrophysiological patch-clamp techniques. However, the most significant aspect of this study refers to the cross-talk between the two main subtypes identified in these cells, the α7- and α3β4* subtypes, aiming to avoid their desensitization. The article also reviews other aspects, including the regulation of their expression, function or physical interaction by choline, Ca2+, and tyrosine and serine/threonine phosphatases. Additionally, the influence of sex on their expression is also discussed.
- Subjects
CHROMAFFIN cells; NICOTINIC receptors; NICOTINIC acetylcholine receptors; MOLECULAR biology; PHYSICAL mobility
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 4, p2304
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25042304