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- Title
Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation.
- Authors
Belov, Konstantin; Brel, Valery; Sobornova, Valentina; Fedorova, Irina; Khodov, Ilya
- Abstract
1,5-Diaryl-3-Oxo-1,4-Pentadiene derivatives are intriguing organic compounds with a unique structure featuring a pentadiene core, aryl groups, and a ketone group. This study investigates the influence of fluorine atoms on the conformational features of these derivatives in deuterated chloroform (CDCl3) solution. Through nuclear magnetic resonance (NMR) spectroscopy and quantum chemical calculations, we discerned variations in interatomic distances and established predominant conformer proportions. The findings suggest that the non-fluorinated entity exhibits a uniform distribution across various conformer groups. The introduction of a fluorine atom induces substantial alterations, resulting in the predominance of a specific conformer group. This structural insight may hold the key to their diverse anticancer activities, previously reported in the literature.
- Subjects
OVERHAUSER effect (Nuclear physics); CONFORMATIONAL analysis; CHEMICAL shift (Nuclear magnetic resonance); NUCLEAR magnetic resonance; INTERATOMIC distances; ARYL group; SPECTROMETRY
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 23, p16707
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242316707