We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances.
- Authors
Golub, Aniela; Ordak, Michal; Nasierowski, Tadeusz; Bujalska-Zadrozny, Magdalena
- Abstract
One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. The aim of this manuscript was to review three advanced markers of hepatotoxicity in psychiatry, namely, osteopontin (OPN), high-mobility group box 1 protein (HMGB1) and glutathione dehydrogenase (GDH, GLDH), and, on this basis, to identify recommendations that should be included in future studies in patients abusing NPSs. This will make it possible to determine whether NPSs do indeed have a hepatotoxic effect or whether other factors, such as additional substances taken or hepatitis C virus (HCV) infection, are responsible. NPS abusers are at particular risk of HCV infection, and for this reason, it is all the more important to determine what factors actually show a hepatotoxic effect in them.
- Subjects
HEPATITIS C virus; HEPATOTOXICOLOGY; BIOMARKERS; PSYCHIATRY; DESIGNER drugs
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 11, p9413
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24119413