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- Title
Novel Insights into the Therapeutic Potential of Curcumin and Derivatives.
- Authors
Bachmeier, Beatrice E.
- Abstract
The polyphenol curcumin (diferuloylmethane) is extracted from the plant turmeric ( I Curcuma longa i ), and it is widely used as a spice component or coloring agent. Although curcumin derivatives seem to exhibit better bioavailability than the lipophilic polyphenol itself, their safety is still to be explored, while curcumin - although less bioavailable - shows promising effects in combination with chemo- and radiotherapy. We know from traditional medicine and many preclinical studies that curcumin has anti-inflammatory properties, which come into effect when it inhibits inflammation-associated signaling pathways, and therefore, it is not surprising that its therapeutic potential against inflammation-associated diseases is currently eagerly explored. Last but not least, Castano and co-workers investigated the inhibitory effects of curcumin on steroid metabolism and tested the effect of curcuminoids on cytochromes P450, and in particular, on the enzymes CYP17A1, CYP21A2, and CYP19A1.
- Subjects
BENZOPYRENE; DNA adducts; CURCUMIN; SPRAGUE Dawley rats
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 10, p8837
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24108837