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- Title
Reverse Translation: The Art of Cyclical Learning.
- Authors
Kasichayanula, Sreeneeranj; Venkatakrishnan, Karthik
- Abstract
We live in an era of precision therapeutics, value‐based healthcare, patient‐participatory research, and enhanced clinical trial transparency, with explosive increases in our ability to access and analyze multiscale biological and clinical data from diverse ecosystems. To discover and develop truly transformative medicines with a patient‐centric sense of urgency, we will need to exploit data that lie far beyond the confines of laboratory‐based experimental models and controlled clinical trials, dynamically maximizing the value of information in real‐world data from clinical practice settings and even social media. This demands commitment to a culture that embraces <italic>Reverse Translation</italic> as a critical component of the practice of Translational Medicine in the discovery, development, regulation, and utilization of therapeutics.
- Subjects
DRUG development; TRANSLATIONAL research; CLINICAL trials; CLINICAL pharmacology; SOCIAL media; THERAPEUTICS
- Publication
Clinical Pharmacology & Therapeutics, 2018, Vol 103, Issue 2, p152
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.952