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- Title
Metformin: Expanding the Scope of Application—Starting Earlier than Yesterday, Canceling Later.
- Authors
Kononova, Yulia A.; Likhonosov, Nikolai P.; Babenko, Alina Yu.
- Abstract
Today the area of application of metformin is expanding, and a wealth of data point to its benefits in people without carbohydrate metabolism disorders. Already in the population of people leading an unhealthy lifestyle, before the formation of obesity and prediabetes metformin smooths out the adverse effects of a high-fat diet. Being prescribed at this stage, metformin will probably be able to, if not prevent, then significantly reduce the progression of all subsequent metabolic changes. To a large extent, this review will discuss the proofs of the evidence for this. Another recent important change is a removal of a number of restrictions on its use in patients with heart failure, acute coronary syndrome and chronic kidney disease. We will discuss the reasons for these changes and present a new perspective on the role of increasing lactate in metformin therapy.
- Subjects
METFORMIN; NUTRITIONALLY induced diseases; ACUTE coronary syndrome; CHRONIC kidney failure; METABOLIC disorders; CARBOHYDRATE metabolism; MONOCARBOXYLATE transporters; CARBOHYDRATE content of food
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 4, p2363
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23042363