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- Title
Mechanism of Phosgene-Induced Acute Lung Injury and Treatment Strategy.
- Authors
Lu, Qianying; Huang, Siyu; Meng, Xiangyan; Zhang, Jianfeng; Yu, Sifan; Li, Junfeng; Shi, Mingyu; Fan, Haojun; Zhao, Yanmei
- Abstract
Phosgene (COCl2) was once used as a classic suffocation poison and currently plays an essential role in industrial production. Due to its high toxicity, the problem of poisoning caused by leakage during production, storage, and use cannot be ignored. Phosgene mainly acts on the lungs, causing long-lasting respiratory depression, refractory pulmonary edema, and other related lung injuries, which may cause acute respiratory distress syndrome or even death in severe cases. Due to the high mortality, poor prognosis, and frequent sequelae, targeted therapies for phosgene exposure are needed. However, there is currently no specific antidote for phosgene poisoning. This paper reviews the literature on the mechanism and treatment strategies to explore new ideas for the treatment of phosgene poisoning.
- Subjects
LUNGS; LUNG injuries; ADULT respiratory distress syndrome; EXPOSURE therapy; PULMONARY edema; PHOSGENE
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 20, p10933
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222010933