We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Responses of the systemic and local vascular renin-angiotensin systems to chronic aerobic exercise training in an angiotensin II infusion model of hypertension.
- Authors
Chung, Justin C. S.; Aultman, Crystal D.; Rush, James W. E.
- Abstract
The renin-angiotensin system (RAS) plays a major role in the pathophysiology of hypertension. In addition, chronic aerobic exercise training is known to improve vasomotor function in various models of hypertension: Thus, we investigated the responses of components from the systemic and local vascular RAS to chronic exercise training in an angiotensin II (AII) infusion model of hypertension. Male Sprague-Dawley rats were exercised trained (EX) for 6 weeks or restricted to cage-bound activity (SED). Osmotic mini-pumps facilitated infusion of AII (0.17mg/day) or vehicle saline (SL) for 3 or 8 days. Plasma AII levels decreased for SED All-infused rats (Day 3: 24.41±5.62pg/mL; Day 8: 9.08±4.83pg/mL) compared to SED SL-infused rats (Day 3: 55.17±0.32pg/mL; Day 8: 55.4±0.55pg/mL) (p<0.01). EX AII-infused rats showed further lowering of plasma AII levels after 3 days (12.4±3.38pg/mL, p<0.01), but not after 8 days. However, an upregulation of ACE protein (+74%) was observed in the abdominal aorta after 8 days of AII-infusion compared to SL-infusion (p<0.05); exercise did not affect this response. MAP increased in SED AII-infused rats (Day 3: 174±2mmHg; Day 8: 194±6mmHg) compared to SED SL-infused rats (Day 3: 127±1mmHg; Day 8: 120±3mmHg) (p<0.01). The present study suggests that both AII-infusion and chronic exercise training affect the systemic and local vascular RAS.
- Subjects
RENIN-angiotensin system; AEROBIC exercises; ANGIOTENSIN II; HYPERTENSION; EXERCISE; LABORATORY rats
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA1365
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.6.a1365-a