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- Title
To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas.
- Authors
Mehta, Aditi; Bajaj, Mandeep; Pushker, Neelam; Chawla, Bhavna; Pujari, Amar; Grewal, Sartaj; Grewal, Satinder; Singh, Simar; Kishore, Alisha; Yadav, Neha; Bajaj, Mandeep S; Grewal, Sartaj S; Grewal, Satinder Pal Singh; Singh, Simar Rajan; Yadav, Neha Singh
- Abstract
<bold>Purpose: </bold>A pilot randomized control trial to compare the efficacy and side effects of intralesional and oral propranolol in periorbital and eyelid capillary hemangiomas.<bold>Methods: </bold>Twenty patients were prospectively randomized to two groups of ten each. Group 1 was initiated on oral propranolol 1 mg/kg/day titrated to final dose of 3 mg/kg/day over 1 week which was continued for 6 months and then tapered over 1 week; Group 2 received 3 doses of direct intralesional propranolol hydrochloride 1 mg/ml; 0.2 ml/cm 4-6 weeks apart. Hemangioma area and corneal astigmatism were measured.<bold>Results: </bold>Within each group at 6 months there was a significant reduction in area (group 1: 83.48 ± 11.67%,P= 0.0019; group 2: 67.78 ± 21.71%,P= 0.0019) and improvement in astigmatism (pre, post: group 1: 2.98D @ 179.8°, 1.13D @ 179.8°,P= 0.0045; group 2: 1.62D @ 90.16°, 0.75D @ 179.9°,P= 0.0001). There was no difference in area reduction (P = 0.056), change in appearance (P = 0.085), ptosis (P = 0.23) and side effects (lethargy, poor feeding;P= 0.171) between the two groups.<bold>Conclusion: </bold>Efficacy and side effects with intralesional propranolol are comparable to oral propranolol for periorbital and eyelid lesions.
- Subjects
PROPRANOLOL; EYELIDS; DRUG side effects; ASTIGMATISM; HEMANGIOMAS; ADRENERGIC beta blockers; COMPARATIVE studies; EYE-socket tumors; EYELID tumors; INJECTIONS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; ORAL drug administration; RESEARCH; PILOT projects; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness
- Publication
Indian Journal of Ophthalmology, 2019, Vol 67, Issue 12, p1974
- ISSN
0301-4738
- Publication type
journal article
- DOI
10.4103/ijo.IJO_59_19