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- Title
Regulation of vascular smooth muscle cell proliferation, migration and death by heparan sulfate 6-O-endosulfatase1
- Authors
Sala-Newby, Graciela B.; George, Sarah J.; Bond, Mark; Dhoot, Gurtej K.; Newby, Andrew C.
- Abstract
Abstract: Migration, proliferation and death of vascular smooth muscle cells (VSMC) are important events in vascular pathology regulated by heparan sulfate proteoglycans and hence potentially by cell surface HS 6-O-endosulfatase1 (sulf1). Sulf1 mRNA expression was increased in cultured VSMC compared to rat aorta. Furthermore, adenovirus mediated overexpression of quail sulf1 decreased adhesion, and increased proliferation and apoptosis of VSMC. Overexpression of a dominant negative variant also decreased adhesion of VSMC and increased proliferation, apoptosis, migration and chemotaxis of VSMC. Our results imply that only normal levels of 6-O-sulfation maintained by sulf1 are optimal for several functions of VSMC.
- Subjects
VASCULAR smooth muscle; MUSCLE cells; APOPTOSIS; MESSENGER RNA
- Publication
FEBS Letters, 2005, Vol 579, Issue 28, p6493
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.10.026