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- Title
Prostaglandin E<sub>2</sub> reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP<sub>3</sub>
- Authors
Yano, Tomohiro; Zissel, Gernot; Muller-Qernheim, Joachim; Jae Shin, Sung; Satoh, Haruna; Ichikawa, Tomio
- Abstract
Prostaglandin E2 (PGE2)-dependent effects on various cell responses are regulated by respective PGE2 receptors (EP1, EP2, EP3, EP4) expressing in target cells. Alveolar type II cell (a main progenitor cell of lung adenocarcinoma) expressed only EP4, while human lung adenocarcinoma cells (A549) expressed EP3 as well as EP4. An antagonistic effect of EP3 against EP4 through the modulation of cyclic AMP level is required for PGE2-mediated activation of Ras signal pathway in A549 cells. These results suggest that the expression of EP3 may be a critical factor for the PGE2-mediated activation of Ras signal pathway in A549 cells.
- Subjects
PROSTAGLANDINS E; ADENOCARCINOMA
- Publication
FEBS Letters, 2002, Vol 518, Issue 1-3, p154
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02689-3