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- Title
A Light‐Driven Molecular Machine Controls K<sup>+</sup> Channel Transport and Induces Cancer Cell Apoptosis.
- Authors
Yang, Huiting; Yi, Jinhao; Pang, Shihao; Ye, Kai; Ye, Zhicheng; Duan, Qi; Yan, Zexin; Lian, Cheng; Yang, Yi; Zhu, Linyong; Qu, Da‐Hui; Bao, Chunyan
- Abstract
The design of artificial ion channels with high activity, selectivity and gating function is challenging. Herein, we designed the light‐driven motor molecule MC2, which provides new design criteria to overcome these challenges. MC2 forms a selective K+ channel through a single molecular transmembrane mechanism, and the light‐driven rotary motion significantly accelerates ion transport, which endows the irradiated motor molecule with excellent cytotoxicity and cancer cell selectivity. Mechanistic studies reveal that the rotary motion of MC2 promotes K+ efflux, generates reactive oxygen species and eventually activates caspase‐3‐dependent apoptosis in cancer cells. Combined with the spatiotemporally controllable advantages of light, we believe this strategy can be exploited in the structural design and application of next‐generation synthetic cation transporters for the treatment of cancer and other diseases.
- Subjects
ION channels; ION transport (Biology); REACTIVE oxygen species; CANCER cells; APOPTOSIS; STRUCTURAL design; MOLECULAR motor proteins
- Publication
Angewandte Chemie, 2022, Vol 134, Issue 26, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202204605