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- Title
<sup>31</sup>P MRSI at 7 T enables high‐resolution volumetric mapping of the intracellular magnesium ion content in human lower leg muscles.
- Authors
Franke, Vanessa L.; Breitling, Johannes; Ladd, Mark E.; Bachert, Peter; Korzowski, Andreas
- Abstract
Purpose: The non‐invasive determination of the free magnesium ion concentration ([Mg2+free]) using 31P MRSI in vivo is of interest in research on various pathologies, e.g. diabetes. The purpose of this study was to demonstrate the potential of 31P MRSI at 7 T to enable volumetric, high‐resolution mapping of [Mg2+free]. Methods: 3D 31P MRSI datasets from the lower leg of three healthy volunteers were acquired at B0 = 7 T with a nominal spatial resolution of (8 × 8 × 16) mm3 in 56 min. Volumetric [Mg2+free] maps were calculated based on the quantified local chemical shift difference between the α‐ and β‐resonance of adenosine triphosphate (ATP) considering also local pH values. Mean [Mg2+free] values from three different muscle groups were compared. To demonstrate the potential of reducing the measurement time, the analysis was repeated on the acquired MRSI data retrospectively reconstructed with fewer averages. Results: The generated [Mg2+free] maps revealed local differences, and mean [Mg2+free] values of (1.08 ± 0.03) mM were found in the tibialis anterior, (0.91 ± 0.04) mM in the soleus and (0.98 ± 0.03) mM in the gastrocnemius medialis. The time‐reduced 28‐min scan resulted in comparable [Mg2+free] maps, and mean values being in agreement with the values from the 56‐min scan. Conclusion: 31P MRSI at 7 T enables volumetric, high‐resolution mapping of free magnesium ion content in human lower leg muscles. The measurement time of the 31P MRSI acquisition can be reduced to 28 min, opening the potential to apply volumetric [Mg2+free] mapping for the investigation of pathologies with altered magnesium homeostasis.
- Subjects
LEG muscles; MAGNESIUM ions; TIBIALIS anterior; ADENOSINE triphosphate; SPATIAL resolution
- Publication
Magnetic Resonance in Medicine, 2022, Vol 88, Issue 2, p511
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.29231