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- Title
High‐resolution quantitative MRI of multiple sclerosis spinal cord lesions.
- Authors
McDowell, Amy R.; Petrova, Natalia; Carassiti, Daniele; Miquel, Marc E.; Thomas, David L.; Barker, Gareth J.; Schmierer, Klaus; Wood, Tobias C.
- Abstract
Purpose: Validation of quantitative MR measures for myelin imaging in the postmortem multiple sclerosis spinal cord. Methods: Four fixed spinal cord samples were imaged first with a 3T clinical MR scanner to identify areas of interest for scanning, and then with a 7T small bore scanner using a multicomponent‐driven equilibrium single‐pulse observation of T1 and T2 protocol to produce apparent proton density, T1, T2, myelin water, intracellular water, and free‐water fraction maps. After imaging, the cords were sectioned and stained with histological markers (hematoxylin and eosin, myelin basic protein, and neurofilament protein), which were quantitatively compared with the MR maps. Results: Excellent correspondence was found between high‐resolution MR parameter maps and histology, particularly for apparent proton density MRI and myelin basic protein staining. Conclusion: High‐resolution quantitative MRI of the spinal cord provides biologically meaningful measures, and could be beneficial to diagnose and track multiple sclerosis lesions in the spinal cord.
- Subjects
SPINAL cord; MYELIN basic protein; MULTIPLE sclerosis; MYELIN sheath diseases; MAGNETIC resonance imaging; HEMATOXYLIN &; eosin staining
- Publication
Magnetic Resonance in Medicine, 2022, Vol 87, Issue 6, p2914
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.29152