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- Title
Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.
- Authors
El Mahdaoui, Amal; Radi, Smaail; Draoui, Youssef; El Massaoudi, Mohamed; Ouahhoud, Sabir; Asehraou, Abdeslam; Bentouhami, Nour Eddine; Saalaoui, Ennouamane; Benabbes, Redouane; Robeyns, Koen; Garcia, Yann
- Abstract
In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L1) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L2), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L1)2](ClO4)2 (C1) and a dinuclear complex [Cd2(L2)2]Cl4 (C2). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L1 and L2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C1 and C2.
- Subjects
CADMIUM compounds; SCHIFF bases; GENETIC toxicology; CRYSTAL structure; PYRAZOLES; AMIDES; CYCLOHEXIMIDE; LIGANDS (Biochemistry)
- Publication
Molecules, 2024, Vol 29, Issue 5, p1186
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29051186