We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bioconjugation of Vegetable Oils with UV Absorbers: New Approach in Skin Photoprotection.
- Authors
Slabu, Andrei Iulian; Miu, Laura; Ghibu, Emilian; Stavarache, Cristina Elena; Stan, Raluca; Teodorescu, Florina
- Abstract
We reported the tunable synthesis of new vegetable oil–UV filter bioconjugates using sea buckthorn oil (SBO) and p-methoxycinnamic acid (p-MCA) as an alternative to the common UV filter, ethylhexyl-p-methoxycinnamate (octinoxate). The synthetic strategy is based on the sustainable ring-opening reaction of epoxidized SBO with p-MCA in heterogenous catalysis in eco-friendly solvents. The amount of UV-absorptive moieties grafted on the triglyceride backbone is controlled by different epoxidation degrees as determined by NMR spectroscopy. The performance of the new UV-absorber bioconjugates was assessed by in vitro sun protection factor (SPF) measurements after inclusion in SBO-ethylcellulose (EC) oleogels and comparison with the SPF value of the SBO-EC-octinoxate oleogel with equivalent p-MCA acid moieties (10% wt/wt). The concentration obtained for the SBO-EC oleogel formulated with the bioconjugate with the lowest degree of functionalization, namely 55%, represents 45% of the SPF determined for the SBO-EC-octinoxate oleogel, regardless of the concentration of measured solutions. The new concept of vegetable oil–UV-absorber bioconjugates has potential UV-B photoprotective properties when included in oleogel formulations and deserves further investigation of their properties and stability including association with UV-A absorbers, respectively.
- Subjects
VEGETABLE oils; SEA buckthorn; RING-opening reactions; BIOCONJUGATES; NUCLEAR magnetic resonance spectroscopy
- Publication
Molecules, 2023, Vol 28, Issue 22, p7550
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28227550