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- Title
Vinylation of N -Heteroarenes through Addition/Elimination Reactions of Vinyl Selenones.
- Authors
Palomba, Martina; Dias, Italo Franco Coelho; Cocchioni, Michelangelo; Marini, Francesca; Santi, Claudio; Bagnoli, Luana
- Abstract
A new protocol for the synthesis of N-vinyl azoles using vinyl selenones and azoles in the presence of potassium hydroxide was developed. This reaction proceeded under mild and transition metal-free conditions through an addition/elimination cascade process. Both aromatic and aliphatic vinyl selenones and various mono-, bi- and tri-cyclic azoles can be tolerated and give terminal N-vinyl azoles in moderate to high yields. A plausible mechanism is also proposed.
- Subjects
ELIMINATION reactions; VINYLATION; POTASSIUM hydroxide
- Publication
Molecules, 2023, Vol 28, Issue 16, p6026
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28166026