We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
K 2 CO 3 -Promoted Formal [3+3]-Cycloaddition of N -Unsubstituted Isatin N , N′ -Cyclic Azomethine Imine 1,3-Dipoles with Knoevenagel Adducts.
- Authors
Yang, Guosheng; Li, Sicheng; Wang, Qiumi; Chen, Huabao; Yang, Chunping; Yin, Zhongqiong; Song, Xu; Zhang, Li; Lu, Cuifen; Yue, Guizhou
- Abstract
The synthesis of dicyclic spiropyridazine oxoindole derivatives by using [3+3]-cycloaddition of N-unsubstituted isatin N,N′-cyclic azomethine imine 1,3-dipoles was reported. The products bearing two consecutive stereocenters, including spiroquaternary stereocenters in one ring structure, can be effectively obtained in moderate to excellent yields (20–93%) and low to moderate diastereoselectivities (1:9–10:1 dr). The synthesized compounds (>35 examples) were characterized by single-crystal XRD, FTIR, NMR, and mass spectral analysis.
- Subjects
SCHIFF bases; PYRIDAZINES; ISATIN; CARBON dioxide; CHEMICAL synthesis
- Publication
Molecules, 2023, Vol 28, Issue 3, p1034
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28031034