We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Benzophenone Rhamnosides and Chromones from Hypericum seniawinii Maxim.
- Authors
Xia, Jing; Hu, Bo; Qian, Mengyu; Zhang, Jiayue; Wu, Lin
- Abstract
Two new benzophenone glycosides, hypersens A and B, along with four known compounds, (S)-(+)-5,7-dihydroxy-2-(1-methylpropyl) chromone (3), 5,7-dihydroxy-2-isopropylchromone (4), urachromone B (5), and 3-8′′ bisapigenin (6), were isolated from Hypericum seniawinii. The structures of new compounds (1 and 2) were elucidated according to comprehensive spectroscopic data analyses. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD) calculations. All isolated compounds were evaluated for their neuroprotective effect using corticosterone-induced PC12 cell injury. In addition, compounds 1–6 were evaluated for their anti-inflammatory activity in lipopolysaccharide-induced RAW 264.7 cells. Compound 6 was a biflavonoid and significantly inhibited the production of nitric oxide with an IC50 value of 11.48 ± 1.23 μM.
- Subjects
HYPERICUM; CHROMONES; ANTI-inflammatory agents; CIRCULAR dichroism; NITRIC oxide; HYDROXYBENZOPHENONES; BENZOPHENONES; GLYCOSIDES
- Publication
Molecules, 2022, Vol 27, Issue 20, p7056
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27207056