We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain.
- Authors
El Daibani, Amal; Che, Tao
- Abstract
In our society today, pain has become a main source of strain on most individuals. It is crucial to develop novel treatments against pain while focusing on decreasing their adverse effects. Throughout the extent of development for new pain therapies, the nociceptin/orphanin FQ receptor (NOP receptor) has appeared to be an encouraging focal point. Concentrating on NOP receptor to treat chronic pain with limited range of unwanted effects serves as a suitable alternative to prototypical opioid morphine that could potentially lead to life-threatening effects caused by respiratory depression in overdose, as well as generate abuse and addiction. In addition to these harmful effects, the uprising opioid epidemic is responsible for becoming one of the most disastrous public health issues in the US. In this article, the contributing molecular and cellular structure in controlling the cellular trafficking of NOP receptor and studies that support the role of NOP receptor and its ligands in pain management are reviewed.
- Subjects
NOCICEPTIN; NOCICEPTORS; NALOXONE; PAIN management; OPIOID receptors; OPIOID epidemic; PUBLIC health
- Publication
Molecules, 2022, Vol 27, Issue 3, p595
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27030595