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- Title
Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer.
- Authors
Fujita, Ken-ichi; Ando, Yuichi; Yamamoto, Wataru; Miya, Toshimichi; Endo, Hisashi; Sunakawa, Yu; Araki, Kazuhiro; Kodama, Keiji; Nagashima, Fumio; Ichikawa, Wataru; Narabayashi, Masaru; Akiyama, Yuko; Kawara, Kaori; Shiomi, Mari; Ogata, Hiroyasu; Iwasa, Hiroyasu; Okazaki, Yasushi; Hirose, Takashi; Sasaki, Yasutsuna
- Abstract
To investigate the effects of genetic polymorphisms on morphine-induced adverse events in cancer patients. We examined the relation of morphine-related adverse events to polymorphisms in UDP-glucuronosyltransferase ( UGT) 2B7, ATP-binding cassette, sub-family B, number 1 ( ABCB1), and μ-opioid receptor 1 genes in 32 Japanese cancer patients receiving oral controlled-release morphine sulfate tablets. The T/T genotype at 1236 or TT/TT diplotype at 2677 and 3435 in ABCB1 was associated with significantly lower frequency of fatigue (grades 1–3) ( P = 0.012 or 0.011, Fisher’s exact test). The UGT2B7*2 genotype was associated with the frequency of nausea (grades 1–3) ( P = 0.023). The frequency of nausea was higher in patients without UGT2B7*2 allele than others. The diplotype at 2677 and 3435 in ABCB1 was associated with the frequency of vomiting (grades 1–3) ( P = 0.011). No patient whose diplotype was consisted of no GC allele at 2677 and 3435 suffered from vomiting. Our findings suggest that pharmacogenetics can be used to predict the risk of morphine-induced adverse events.
- Subjects
GENETIC polymorphisms; CANCER patients; MORPHINE; GLUCURONOSYLTRANSFERASE; OPIOIDS; NAUSEA
- Publication
Cancer Chemotherapy & Pharmacology, 2010, Vol 65, Issue 2, p251
- ISSN
0344-5704
- Publication type
Article
- DOI
10.1007/s00280-009-1029-2