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- Title
Selective localization of γ-enolase in stromal cells of cerebellar hemangioblastomas.
- Authors
Feldenzer, J.; McKeever, P.
- Abstract
Three cases of cerebellar hemangioblastoma were studied using the immunoperoxidase technique to localize γ-enolase, also known as neuron-specific enolase. The stromal cells demonstrated positive staining for γ-enolase, while endothelial cells and pericytes showed no reactivity. Two vascular lesions, an angiosarcoma and a cutaneous angioma, were studied and found to be nonreactive for γ-enolase. All tumors were also tested for factor VIII/von Willebrand factor, glial fibrillary acidic protein, and the S-100 protein. The lack of expression of γ-enolase in endothelial cells of hemangioblastomas demonstrates a clear antigenic distinction from neighboring γ-enolase-positive stromal cells. The significance of this finding and its implications for stromal cell histogenesis are discussed.
- Publication
Acta Neuropathologica, 1986, Vol 72, Issue 3, p281
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/BF00691102