Title

Yaşlanma ve Sirkadiyen Ritmin Moleküler Mekanizmaları.

Authors

FINDIK KIYAN, Hilal; KIYAN, Toros

Abstract

Organizations have been adapting to the 24-hour day/night cycle. These circadian rhythms are produced by an internal cellular mechanism that controls physiological and metabolic processes. In the aging process the circadian system is weakening and biological changes are slowing down. The genetic change of circadian genes and the deterioration of the molecular clock are related to the aging process. In addition, environmental conditions (eg; calorie restriction) are important factors affecting the aging process. Intracellular pathways involving nutritional sensors influence cellular and epigenetic mechanisms that control the aging process. Studies have shown that these pathways are involved in both the modulation of the aging process and the control of the molecular clock. Therapeutic strategies focused at controlling the circadian clock and the nutrient sensing pathways might beneficially influence the negative effects of aging and make more efficient this process.

Publication

Turkiye Klinikleri Journal of Health Sciences / Türkiye Klinikleri Sağlık Bilimleri Dergisi, 2019, Vol 4, Issue 3, p400

ISSN

2536-4391

Publication type

Academic Journal

DOI

10.5336/healthsci.2018-63684