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- Title
The Effect of Galantamine on Lipopolysaccharide-induced Acute Lung Injury During Neutropenia Recovery in Mice.
- Authors
OH BEOM KWON; WAN SEO; KYU YEAN KIM; HYONSOO JOO; CHANG DONG YEO; JIN WOO KIM
- Abstract
Background/Aim: Acute lung injury (ALI) is associated with a high mortality rate and cancer patients who receive chemotherapy are at high risk of ALI during neutropenia recovery. Galantamine is a cholinesterase inhibitor used for Alzheimer's disease treatment. Previous studies have shown that galantamine reduced inflammatory response in lipopolysaccharide (LPS)-induced ALI in rats. Mer protein was negatively associated with inflammatory response. The aim of the study was to investigate whether galantamine is effective in LPS-induced ALI during neutropenia recovery and its effect on Mer tyrosine kinase (MerTK) expression in mice. Materials and Methods: Intraperitoneal cyclophosphamide was given to mice to induce neutropenia. After 7 days, LPS was administered by intratracheal instillation. Intraperitoneal galantamine was given once before LPS administration and in another group, galantamine was given twice before LPS administration. Results: Galantamine attenuated LPS-induced ALI in histopathological analysis. The neutrophil percentage was lower in the group where galantamine was injected once, compared to the LPS group (p=0.007). MerTK expression was also higher in the group where galantamine was injected once but did not reach statistical significance (p=0.101). Conclusion: Galantamine attenuated inflammation in LPS-induced ALI during neutropenia recovery.
- Subjects
LUNG injuries; GALANTHAMINE; LIPOPOLYSACCHARIDES; NEUTROPENIA; LABORATORY mice
- Publication
In Vivo, 2024, Vol 38, Issue 2, p606
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13479