We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Continuity of Tumor Microenvironmental Suppression in AOM/DSS Mice by Fucoxanthin May Be Able to Track With Salivary Glycine.
- Authors
MASARU TERASAKI; RYOTA KIMURA; ATSUHITO KUBOTA; HIROYUKI KOJIMA; TAKUJI TANAKA; HAYATO MAEDA; KAZUO MIYASHITA; MICHIHIRO MUTOH
- Abstract
Background/Aim: Fucoxanthin (Fx) is a potent anticancer carotenoid, demonstrated by mouse cancer models. We recently showed the decrease of salivary glycine could represent an attenuation of tumor microenvironment (TME) formation in an azoxymethane/dextran sodium sulfate (AOM/DSS) colon cancer mouse model. However, it remains unclear whether the salivary glycine is an indicator for continuous TME suppression of Fx in the mice. Materials and Methods: In the present study, we time-dependently analyzed salivary metabolites in AOM/DSS mice, and investigated candidate markers to evaluate the continuous inhibition of colonic TME formation and carcinogenesis in the mice with and without Fx. Results: Fx attenuated the incidence and/or multiplicity of colonic lesions developed in AOM/DSS mice. The number of apoptosis-like cleaved caspase-3high cells was significantly increased, and colonic cancer stem cell-like CD44high/EpCAMhigh cells and cancerassociated fibroblast-like αSMAhigh cells were significantly decreased in colon mucosal tissue by Fx administration.
- Subjects
TUMOR microenvironment; TUMOR treatment; CAROTENOIDS; ANTINEOPLASTIC agents; PHYSIOLOGICAL effects of glycine; ANIMAL models of cancer
- Publication
In Vivo, 2020, Vol 34, Issue 6, p3205
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.12156