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- Title
Single Short Retention Instillation of Pirarubicin Prevents Intravesical Recurrence of Low-risk Non Muscle Invasive Bladder Cancer.
- Authors
KAGEYAMA, SUSUMU; MAEDA, KOKI; KUBOTA, SHIGEHISA; YOSHIDA, TETSUYA; OSAFUNE, TAKASHI; ARAI, YUTAKA; SOGA, HIROKI; NISHIKAWA, ZENKAI; SAKANO, YUJI; TAKIMOTO, KEITA; KIM, CHUL JANG; CHANO, TOKUHIRO; KAWAUCHI, AKIHIRO
- Abstract
Background: This study evaluated the efficacy of a single instillation of pirarubicin with a short retention time for preventing intravesical recurrence of low-risk non-muscle-invasive bladder cancer. Patients and Methods: We analyzed 165 patients with low-risk non-muscle-invasive bladder cancer who underwent transurethral surgery. Single instillation of pirarubicin with 15-min retention time immediate after surgery was performed in 47 (28%) patients. The other patients (118, 72%) were treated without instillation therapy. The primary endpoint was recurrence-free survival. Results: Median overall follow-up was 50 (range=6-134) months. Recurrence-free survival at 1 and 5 years was 91% and 72%, and 79% and 54% in the group treated with pirarubicin, and that treated with surgery alone, respectively (p=0.031). Cox’s hazard analysis revealed lack of instillation and larger tumor size (>10 mm) as significant factors for risk of recurrence. No adverse events regarding intravesical chemotherapy were observed. Conclusion: Pirarubicin instillation with 15-min retention time can prevent intravesical recurrence of low-risk bladder tumors.
- Subjects
BLADDER cancer prevention; BLADDER cancer treatment; CANCER chemotherapy; TUMORS; CANCER treatment
- Publication
In Vivo, 2021, Vol 35, Issue 2, p1141
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.12360