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- Title
A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists.
- Authors
Hurley, M. Yadira; George, Mary Noel; Leonardi, Craig L.; Frater, John L.
- Abstract
Background: Therapeutic biologic agents are uncommonly associated with lymphoma. Case presentation: We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva®) and etanercept (Enbrel®), who developed painless lymphadenopathy with peripheral lymphocytosis during treatment, simulating a non-Hodgkin lymphoma clinically and pathologically. Lymphocytosis and lymphadenopathy spontaneously remitted following cessation of etanercept therapy and have not recurred. Conclusion: Distinction between clinically benign lymphoid proliferations related to antipsoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy.
- Subjects
LYMPHOMAS; T cells; PSORIASIS; TUMOR necrosis factors; PATIENTS
- Publication
Diagnostic Pathology, 2008, Vol 3, p1
- ISSN
1746-1596
- Publication type
Case Study
- DOI
10.1186/1746-1596-3-13