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- Title
Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention.
- Authors
Braddock, Martin; Quinn, Anthony
- Abstract
The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a wide range of inflammatory responses in a number of cell types. Biological agents that target IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-1 pathway, are being investigated as new drugs for the management of inflammatory disease. Such compounds will have wide utility in numerous inflammatory conditions.
- Subjects
INFLAMMATION treatment; CYTOKINES; INTERLEUKIN-1; RHEUMATOID arthritis; PHARMACEUTICAL research; DRUG development
- Publication
Nature Reviews Drug Discovery, 2004, Vol 3, Issue 4, p1
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd1342