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- Title
Premorbid aspirin use is not associated with lower mortality in older inpatients with SARS-CoV-2 pneumonia.
- Authors
Sullerot, Coralie; Bouiller, Kevin; Laborde, Caroline; Gilis, Marine; Fèvre, Amélie; Hacquin, Arthur; Manckoundia, Patrick; Hoefler, Florence; Bermejo, Messaline; Mendes, Aline; Serratrice, Christine; Prendki, Virginie; Sanchez, Stéphane; Putot, Alain
- Abstract
Platelet aggregation has been associated with COVID-19 pathogenesis. In older patients hospitalized for SARS-CoV-2 pneumonia, we aimed to investigate the association between aspirin use before admission and the risk of in-hospital all-cause mortality. We performed a retrospective international cohort study in five COVID-19 geriatric units in France and Switzerland. Among 1,357 consecutive hospitalized patients aged 75 or older and testing positive for SARS-CoV-2, we included 1,072 with radiologically confirmed pneumonia. To adjust for confounders, a propensity score for treatment was created, and stabilized inverse probability of treatment weighting (SIPTW) was applied. To assess the association between aspirin use and in-hospital 30-day mortality, SIPTW-adjusted Kaplan–Meier and Cox proportional hazards regression analyses were performed. Of the 1047 patients with SARS-CoV-2 pneumonia and median age 86 years, 301 (28.7%) were taking aspirin treatment before admission. One hundred forty-seven (34.3%) patients who had taken aspirin died in hospital within 1 month vs 118 patients (30.7%) without aspirin. After SIPTW, aspirin treatment was not significantly associated with lower mortality (adjusted hazard ratio: 1.10 [0.81–1.49], P =.52). Moreover, patients on aspirin had a longer hospital stay and were more frequently transferred to the intensive care unit. In a large multicenter cohort of older inpatients with SARS-CoV-2 pneumonia, aspirin use before admission did not appear to be associated with an improved prognosis.
- Publication
GeroScience, 2022, Vol 44, Issue 2, p573
- ISSN
2509-2715
- Publication type
Article
- DOI
10.1007/s11357-021-00499-8