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- Title
黄芩清热除痹胶囊配合中药外敷治疗急性痛风性关节炎的效果及对细胞因子的影响.
- Authors
王桂珍; 刘健; 黄传兵; 谌曦; 张皖东; 汪元; 曹云祥; 纵瑞凯; 孙癑
- Abstract
Objective To observe the efficacy and cytokines of using Huangqin Qingre Chubi capsule orally united with Furong Ointment external application to treat acute gouty arthritis(AGA) patients.Methods 92 AGA patients were assigned randomly to treatment group and control group.Both groups were given non-steroidal anti-inflammatory drugs,and the treatment group were given Huangqin Qingre Chubi capsule orally united with Furong Ointment external application on swelling joints.And a healthy normal group of 46 cases was established.Enzyme linked immunosorbent assay (ELISA) were employed to measure the expression levels of IL-1β,TNF-α,IL-4,IL-10.Erythrocyte sedimentation rate (ESR) was detected by Instrument method.C-reactive protein were detected by automatic biochemical analyzer.Observed VAS,Joint swelling score and TCM syndrome score in two groups of patients.Results The total effective rate was 93.48% in the treatment group and 76.09% in the control group,which was significantly better than that in the control group (P<0.05).VAS,Joint swelling score,TCM syndrome score,ESR and hs-CRP were significantly decreased after treatment in two groups(P<0.01),VAS,Joint swelling score,ESR and hs-CRP were more significantly decreased compared with after control group(P<0.05 or P<0.01).Compared with normal control group,level of IL-1β and TNF-ɑ were significantly increased,IL-4 and IL-10 were significantly decreased(P<0.01);TNF-a and IL-1β were significantly decreased,IL-4 and IL-10 were significantly increased after treatment in two groups(P<0.05 or P<0.01).Conclusion Huangqin Qingre Chubi capsule orally united with Furong Ointment external application is effective in treating AGA,which could not only significantly improve the clinical symptoms of the patients,but also significantly reduce the inflammatory response.
- Publication
Chinese Journal of Clinical Healthcare, 2021, Vol 24, Issue 2, p209
- ISSN
1672-6790
- Publication type
Article
- DOI
10.3969/J.issn.1672-6790.2021.02.014