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- Title
Amelioration of streptozotocin-induced diabetes by Agrocybe chaxingu polysaccharide.
- Authors
Lee, Byung; Lee, Yeom; Kim, Dae; Song, Ha; Yoo, Ki-Yeon; Won, Moo; Kang, Tae-Cheon; Lee, Kwang; Kim, Kyung; Joo, Jin; Ham, Hun; Hur, Jang; Cho, Sung-Woo; Han, Kyu; Lee, Kil; Park, Jinseu; Eum, Won; Choi, Soo
- Abstract
The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic β-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic β-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.
- Publication
Molecules & Cells (Springer Nature), 2010, Vol 29, Issue 4, p349
- ISSN
1016-8478
- Publication type
Article
- DOI
10.1007/s10059-010-0044-9