We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Helicobacter Pylori: Pathophysiology, Prevalence, Risk Factors, Diagnosis and Treatment.
- Authors
Karakuş, Volkan; Dere, Özcan; Dere, Yelda; Kurtoğlu, Erdal
- Abstract
Helicobacter pylori (H pylori) is a spiralshaped, flagellated, micro- aerophilic gram-negative bacillus that colonizes the gastric mucosa of more than 50% of the human population. There are different findings for the prevalence of H pylori across the world with the highest prevalence in developing countries. Most of the reports on risk factors focused on socioeconomic indicators. Its relationship with gastritis and peptic ulcer in humans was proven. The infection is transmitted within the family in childhood, likely by oral transmission. Urea breath test, stool antigen test, antibody detection, endoscopy, histology, urease test, and culture are used for the diagnosis. Antibiotics and antiacidics are not sufficient alone, therefore combination treatment is preferred. Pretreatment with N-acetylcysteine as a mucolytic agent to destroy the biofilm of H pylori is effective. The addition of probiotics such as Lactobacillus spp., Saccharomyces spp., Bifidobacterium spp., and Bifidobacterium clausii as an adjunctive agent is another approach. If the first-line therapy fails, the second-line options should include different antibiotics.
- Subjects
HELICOBACTER pylori infections; DISEASE prevalence; PATHOLOGICAL physiology; INFECTIOUS disease transmission; DIAGNOSIS; DISEASE risk factors
- Publication
Kafkas Journal of Medical Sciences / Kafkas Tıp Bilimleri Dergisi, 2018, Vol 8, Issue 1, p105
- ISSN
2146-2631
- Publication type
Article
- DOI
10.5505/kjms.2016.37431