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- Title
The prognostic impact of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-tolymphocyte ratio in patients with advanced colorectal cancer treated with first-line chemotherapy.
- Authors
Krakowska, Magdalena; Dębska-Szmich, Sylwia; Czyżykowski, Rafał; Zadrożna-Nowak, Anna; Potemski, Piotr
- Abstract
Introduction: Colorectal cancer is the second most frequently diagnosed malignancy and one of the leading causes of cancer- related death in Poland. Many reports of different types of cancer have indicated that blood count parameters may serve as a source of prognostic or predictive information. Aim: To assess the association between these parameters and clinical outcome in patients with advanced colorectal cancer. Material and methods: We retrospectively analysed a database of 295 patients with advanced colorectal cancer treated with first-line palliative chemotherapy at our institution from January 2008 to December 2012. Blood-based parameters were measured before the first cycle of treatment. Results: The median progression-free survival (PFS) was 6.7 months, and the median overall survival was 17.6 months. A high neutrophil-to-lymphocyte ratio (NLR) and a high platelet-to-lymphocyte ratio (PLR) were associated with a shorter survival (hazard ratio (HR): 1.88, p < 0.0001 for the NLR and HR: 1.39, p = 0.0054 for the PLR), but for the PLR, we observed only a not significant trend toward a worse PFS (HR = 1.25, p = 0.07 for the PLR and HR = 1.55, p = 0.0004 for the NLR). A high lymphocyte- to-monocyte ratio (LMR) was associated with a better prognosis (HR = 0.58, p ≤ 0.0001) and a longer PFS (HR = 0.73, p = 0.011). Conclusions: The blood-based parameters are readily available, reliable, and low-cost biomarkers, which can be easily incorporated into routine practice to predict the prognosis in patients with advanced colorectal cancer.
- Subjects
COLON cancer; CANCER treatment; CANCER chemotherapy
- Publication
Gastroenterology Review / Przegląd Gastroenterologiczny, 2018, Vol 13, Issue 3, p218
- ISSN
1895-5770
- Publication type
Article
- DOI
10.5114/pg.2018.78287