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- Title
Hepatotoxicity of Cassia fistula extracts in experimental chicks and assessment of clinical parameters.
- Authors
Iqbal, Irfana; Afzal, Mohammad; Aftab, Muhammad N.; Manzoor, Farkhanda; Kaleem, Afshan; Kaleem, Ahmad
- Abstract
Cassia fistula (Fabaceae) is one of the most commonly used medicinal plants for its antimalarial and antimicrobial activities. So far, safety of the plant fruit seed as a traditional medicine has not been well investigated. Therefore, the effect of C. fistula seeds on sub-chronic hepatic toxicity in chicks fed with 30-50 mg/kg methanolic extract of the fruit seeds, for 7-21 days, was investigated. The protective effect of C. fistula on organs and the hematological and biochemical parameters were examined. At 40 mg/kg dose of C. fistula to chicks showed a non-significant decrease in count of RBCs and other serological values, presumably through a provoked hemolysis of RBCs and/or toxicity of the plant. However, a significant reduction in liver function enzymes (ALP, ALT and AST) urea, and creatinine levels with an increase in plasma protein reflected on its hepato-renal protection. Only nominal pathological lesions were observed in microscopic examination of the chick's hepatic tissues. We propose that C. fistula fruit seeds are hepatoprotective and renoprotective.
- Subjects
HEPATOTOXICOLOGY; CASSIA fistula; ANTIMALARIALS; THERAPEUTIC use of plant extracts; ANTI-infective agents; CHICKS; DISEASES
- Publication
Kuwait Journal of Science, 2016, Vol 43, Issue 3, p135
- ISSN
2307-4108
- Publication type
Article