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- Title
Efficacy of low-dose rituximab in combination with recombinant human thrombopoietin in treating ITP.
- Authors
LI, Y.; WANG, Y.-Y.; FEI, H.-R.; WANG, L.; YUAN, C.-L.
- Abstract
OBJECTIVE: This work aims to observe the efficacy and safety of low-dose rituximab in combination with recombinant human thrombopoietin in treating immune thrombocytopenia (ITP). PATIENTS AND METHODS: Fourteen ITP patients were treated four times with 100 mg qw of rituximab in combination with 300 µg/kg/d ih recombinant human thrombopoietin (rhTPO) for 14 d. Platelet count in peripheral blood, serum immunoglobulin, and lymphocyte subgroups by flow cytometry were detected regularly both pre- and post-treatment. RESULTS: Among the 14 patients, seven complete responses, six responses, and one no response were obtained, with an overall response of 93%. CONCLUSIONS: Low-dose rituximab in combination with rhTPO is effective in treating ITP.
- Subjects
DRUG efficacy; RITUXIMAB; ANTINEOPLASTIC agents; THROMBOPOIETIN; IDIOPATHIC thrombocytopenic purpura; THROMBOPENIC purpura treatment; THERAPEUTICS
- Publication
European Review for Medical & Pharmacological Sciences, 2015, Vol 19, Issue 9, p1583
- ISSN
1128-3602
- Publication type
Article