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- Title
Synthesis, single crystal x-ray analysis, and antimicrobial activity of new (22E)- N'-(4-methoxybenzylidene)-2-[3-cyano-7,8-dihydro-4-(5-methylfuran-2-yl)-2-oxo-2 H-pyrano[4,3- b]pyridin-1(5 H)-yl]acetohydrazide.
- Authors
Amr, A.; Mohamed, S.; Al-Omar, M.; Ghabbour, H.
- Abstract
(22E)- N'-(4-Methoxybenzylidene)-2-[3-cyano-7,8-dihydro-4-(5-methylfuran-2-yl)-2-oxo-2 H-pyrano[ 4,3- b]pyridin-1(5 H)-yl]acetohydrazide (2) was synthesized from 2-[3-cyano-7,8-dihydro-4-(5-methylfuran- 2-yl)-2-oxo-2H-pyrano[4,3- b]pyridin-1(5 H)-yl]acetohydrazide (1) as starting material with 4-methoxybenzaldehyde. The product 22 was evaluated for antimicrobial activity against gram positive and gram negative bacteria in comparison with Vebromycine as the standard antibiotics. Compound 2, CHNO, crystallized as triclinic, P-1, a = 8.3496(5) Å, b = 10.9465(9) Å, c = 12.1495(9) Å, a = 74.694(4)°, β = 84.793(3)°, γ = 84.495 (3)°, V = 1063.64(13) Å, Z = 2.
- Subjects
BENZENE compound synthesis; FURANS synthesis; PYRIDINE synthesis; METHYL groups; ANTIBIOTICS
- Publication
Russian Journal of General Chemistry, 2016, Vol 86, Issue 7, p1758
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363216070367