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- Title
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis.
- Authors
Tappia, Paramjit S.; Ramjiawan, Bram; Dhalla, Naranjan S.
- Abstract
The article discusses the role of cardiomyocyte phospholipase C (PLC) isozymes in the catecholamine-induced increase in protein synthesis by using a blocker of α1-AR and an inhibitor of PLC. It mentions that the α1-AR-Gqα-PLC-mediated hypertrophic signalling pathway may complement the other β1-AR-Gs protein-adenylyl cyclase signal transduction mechanisms in the early stages of cardiac hypertrophy development, but may become more relevant at the late stage of cardiac hypertrophy.
- Publication
Canadian Journal of Physiology & Pharmacology, 2022, Vol 100, Issue 10, p945
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2022-0189