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- Title
The effect of the learning curve on paravalvular aortic regurgitation and mid‐term mortality in transfemoral transcatheter aortic valve implantation.
- Authors
Istrate, Mihnea; Dregoesc, Mihaela I.; Bolboacă, Sorana D.; Botiș, Cătălin; Ștef, Adrian; Bindea, Dan I.; Oprea, Alexandru; Trifan, Cătălin A.; Moț, Ștefan D. C.; Molnar, Adrian; Iancu, Adrian C.
- Abstract
Objective: Paravalvular aortic regurgitation is an important independent mortality predictor in transcatheter aortic valve implantation (TAVI). Our study evaluated the association between paravalvular aortic regurgitation and mid‐term mortality in relation with the learning curve, in patients with severe aortic stenosis who underwent transfemoral TAVI in the first 3 years since the establishment of the program. Methods: Patients with severe aortic stenosis who underwent transfemoral TAVI between 2017 and 2020 were included in the analysis. Paravalvular aortic regurgitation was assessed by transthoracic echocardiography at 48 hours after the procedure. All‐cause mortality was evaluated after 30 days and at mid‐term follow‐up. Results: Paravalvular aortic regurgitation ≥grade II was associated with mid‐term all‐cause mortality (OR 4.4; 95%CI 1.82–11.55; p < 0.001), their prevalence declining after the first 60 cases. Baseline characteristics did not significantly differ in the first 60 patients from the rest of the cohort. Male sex (p = 0.006), advanced age (p = 0.04), coronary artery disease (p = 0.003), or elevated STS Score (p = 0.02) influenced mid‐term survival. When adjusting for the presence of these factors, only age (OR 1.1; 95%CI 1.0–1.2), paravalvular aortic regurgitation ≥grade II (OR 3.9; 95%CI 1.3–12.9), and the number of days spent in the intensive care unit (OR 1.4; 95%CI 1.1–1.8) were independent predictors of mid‐term all‐cause mortality. Conclusions: In a group of patients with severe aortic stenosis who underwent transfemoral TAVI in the first 3 years since the establishment of the program, paravalvular aortic regurgitation ≥grade II was associated with mid‐term mortality, both declining after the first 60 cases.
- Subjects
ECHOCARDIOGRAPHY; HEART valve prosthesis implantation; CONFIDENCE intervals; AGE distribution; AORTIC stenosis; SURGICAL complications; LEARNING; SEX distribution; DESCRIPTIVE statistics; KAPLAN-Meier estimator; CORONARY artery disease; AORTIC valve insufficiency; ODDS ratio; DATA analysis software; LONGITUDINAL method
- Publication
Echocardiography, 2022, Vol 39, Issue 2, p204
- ISSN
0742-2822
- Publication type
Article
- DOI
10.1111/echo.15289