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- Title
Comparison of esophageal acid exposure at 1 cm and 6 cm above the squamocolumnar junction using the Bravo™ pH monitoring system.
- Authors
Pandolfino, J. E.; Lee, T. J.; Schreiner, M. A.; Zhang, Q.; Roth, M. P.; Kahrilas, P. J.
- Abstract
The aim of this study was to assess the quantitative differences of acid exposure at 1 cm and 6 cm above the squamocolumnar junciton (SCJ) using two radiotelemetry pH capsules affixed to the esophageal mucosa. Ten normal subjects and 10 endoscopy-negative gastroesophageal reflux disease (GERD) patients without hiatus hernia (ages 20–54, 12 male) were studied for a 24-h period using the Bravo™ pH monitoring system. pH capsules were placed 1 cm and 6 cm above the SCJ. Interpretable data for at least 14 h was obtained in 18 of the 20 subjects (9 normal, 9 GERD). Two failures occurred secondary to early capsule dislodgement. Median esophageal acid exposure was significantly increased at 1 cm above the SCJ compared to 6 cm above the SCJ during the total, upright and postprandial time periods in both normal and GERD subjects. During a 2 h postprandial period the esophageal acid exposure was 8-fold greater in GERD subjects and 5-fold greater in normal subjects 1 cm above the SCJ compared to 6 cm above the SCJ. Confident measurement of esophageal acid exposure at a fixed position 1 cm above the SCJ is feasible with the Bravo system. Acid exposure was significantly higher 1 cm above the SCJ compared to 6 cm above the SCJ in both GERD patients and controls. These findings suggest that measurement of acid exposure 1 cm above the SCJ may improve accuracy of pH monitoring by detecting acid reflux events confined to the distal esophagus.
- Subjects
ESOPHAGUS diseases; GASTROESOPHAGEAL reflux; PHYSIOLOGICAL effects of acids; HIATAL hernia; ESOPHAGUS; CASE studies
- Publication
Diseases of the Esophagus, 2006, Vol 19, Issue 3, p177
- ISSN
1120-8694
- Publication type
Article
- DOI
10.1111/j.1442-2050.2006.00561.x