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- Title
Association between Relative Thrombocytosis and Microalbuminuria in Adults with Mild Fasting Hyperglycemia.
- Authors
Choi, Jong Wook; Kim, Tae Hoon; Park, Joon-Sung; Lee, Chang Hwa
- Abstract
An elevated platelet count may contribute to significant thrombotic events and pose a risk for diabetic microvascular complications. Albuminuria, one of the hallmarks of diabetes, is thought to be a risk factor for endothelial dysfunction. In this study, we investigated the association between relative thrombocytosis and an increased urine albumin-to-creatinine ratio in healthy adult participants. Using multivariate analyses on data from the Korea National Health and Nutrition Examination Survey V–VI, 12,525 eligible native Koreans aged ≥ 20 were categorized into platelet count quintiles by sex. The highest platelet count quintile included younger, more obese participants with elevated white blood cell counts, poor lipid profiles, and a better estimated glomerular filtration rate. Restricted cubic spline regression analysis revealed significant associations between platelet count and fasting blood glucose, glycated hemoglobin, and urine albumin-to-creatinine ratio. Adjusted logistic regression models indicated that heightened fasting blood glucose and platelet count were linked to risk of microalbuminuria (fasting blood glucose, odds ratio = 1.026, 95%CI = 1.011–1.042; platelet count, odds ratio = 1.004, 95%CI = 1.002–1.006). Particularly, an increased platelet count was notably associated with microalbuminuria progression in subjects with impaired fasting glucose. These findings suggest that an elevated platelet count, even below diagnostic thrombocytosis levels, independently correlates with an increased risk of vascular endothelial dysfunction in patients with impaired fasting glucose.
- Subjects
LEUKOCYTE count; PLATELET count; BLOOD platelets; THROMBOCYTOSIS; ALBUMINURIA
- Publication
Journal of Personalized Medicine, 2024, Vol 14, Issue 1, p89
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm14010089