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- Title
The pathological features of idiopathic interstitial pneumonia-associated pulmonary adenocarcinomas.
- Authors
Kojima, Yoko; Okudela, Koji; Matsumura, Mai; Omori, Takahiro; Baba, Tomohisa; Sekine, Akimasa; Woo, Tetsukan; Umeda, Shigeaki; Takemura, Tamiko; Mitsui, Hideaki; Suzuki, Takehisa; Tateishi, Yoko; Iwasawa, Tae; Arai, Hiromasa; Tajiri, Michihiko; Ogura, Takashi; Kameda, Yoichi; Masuda, Munetaka; Ohashi, Kenich
- Abstract
Aims To investigate the pathological features of idiopathic interstitial pneumonia ( IIP)-associated pulmonary adenocarcinoma. Methods and results Surgically resected adenocarcinomas associated with IIP (the IIP group) and adenocarcinomas without IIP (the non- IIP group) were subjected to analysis. Adenocarcinomas in the IIP group were subdivided into two groups: one group included tumours connected to bronchiolar metaplasia in honeycomb lesions (the H- IIP group), and the other included tumours unrelated to honeycomb lesions (the NH- IIP group). Histomorphological appearance and immunohistochemical expression were compared among the H- IIP group, the NH- IIP group, and the non- IIP group. Most of the tumour cells in the H- IIP group had a tall, columnar shape that showed similar features to proximal bronchial epithelium, whereas tumour cells in the NH- IIP group and the non- IIP group had a club-like shape that showed similar features to respiratory bronchiolar/alveolar epithelium. Adenocarcinomas in the H- IIP group tended to be negative for thyroid transcription factor-1 ( TTF-1) and positive for hepatocyte nuclear factor-4α ( HNF-4α). The frequency of EGFR mutations was significantly lower in adenocarcinomas in the H- IIP group, although the frequencies of KRAS and ALK mutations did not differ among the three groups. Conclusions Idiopathic interstitial pneumonia-associated pulmonary adenocarcinomas, especially those arising from honeycomb lesions, have distinct pathological features.
- Subjects
IDIOPATHIC pulmonary fibrosis; BRONCHOALVEOLAR lung cancer; HISTOPATHOLOGY; METAPLASIA; CANCER cell variation; GENETIC mutation; EPIDERMAL growth factor receptor genetics; HEPATOCYTE nuclear factors
- Publication
Histopathology, 2017, Vol 70, Issue 4, p568
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.13103