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- Title
Reduced expression of α Glc NAc in Barrett's oesophagus adjacent to Barrett's adenocarcinoma - a possible biomarker to predict the malignant potential of Barrett's oesophagus.
- Authors
Iwaya, Yugo; Hasebe, Osamu; Koide, Naohiko; Kitahara, Kei; Suga, Tomoaki; Shinji, Akihiro; Muraki, Takashi; Yokosawa, Shuichi; Yamada, Shigenori; Arakura, Norikazu; Tanaka, Eiji; Nakayama, Jun
- Abstract
Aims Gastric gland mucin contains O-glycans exhibiting terminal α1,4-linked N-acetylglucosamine residues (αGlc NAc). Recently we demonstrated that mice deficient in αGlc NAc in gastric gland mucin develop gastric adenocarcinoma spontaneously, indicating that αGlc NAc is a tumour suppressor for gastric cancer. However, the role of αGlc NAc in Barrett's oesophagus ( BO) remains unknown. In this study, we investigated whether reduced αGlc NAc expression in BO is associated with development of Barrett's adenocarcinoma ( BAC). Methods and results Thirty-five BO lesions adjacent to BAC were examined by immunohistochemistry for αGlc NAc, MUC6 and CDX2. As controls, 35 BO lesions without BAC obtained from patients with oesophageal squamous cell carcinoma were also analysed. Expression of αGlc NAc relative to its scaffold MUC6 in BO adjacent to BAC was reduced significantly compared to control BO. Decreased αGlc NAc expression in BO adjacent to BAC was particularly significant in patients with smaller tumour size (<20 mm) and minimal invasion of tumour cells to the superficial muscularis mucosae. There was also a significant inverse correlation between αGlc NAc and CDX2 expression in BO adjacent to BAC. Conclusions Decreased expression of αGlc NAc compared with MUC6 in BO is a possible hallmark in predicting BAC development.
- Subjects
ESOPHAGEAL cancer; BIOMARKERS; GLYCOASPARAGINASE; LABORATORY mice; ADENOCARCINOMA; SQUAMOUS cell carcinoma
- Publication
Histopathology, 2014, Vol 64, Issue 4, p536
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.12296