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- Title
Editorial: Synthetic peptide vaccine platforms targeting tumor-specific antigens: advances and challenges.
- Authors
Rubsamen, Reid M.; Sloan, Andrew E.
- Abstract
This article is an editorial published in Frontiers in Pharmacology titled "Synthetic peptide vaccine platforms targeting tumor-specific antigens: advances and challenges." The authors discuss the discovery and therapeutic aspects of peptide vaccine platforms, specifically in relation to identifying potential antigen targets on tumors and strategies to enhance their immunogenicity. The article highlights advancements in computational techniques for identifying immunogenic peptide antigens, as well as the use of toll-like receptor agonists to improve the immunogenicity of vaccines. The authors emphasize the importance of confirming peptide binding characteristics through in-vivo or in-vitro determination. The article concludes by discussing the potential advantages of synthetic peptide vaccine platforms and the increasing tools available for designing peptide vaccines for oncology applications.
- Subjects
PEPTIDE vaccines; ANTIGENS; VIRUS-like particles; T cell receptors; PROTEIN structure prediction; MOLECULAR biology; CANCER vaccines
- Publication
Frontiers in Pharmacology, 2024, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2024.1363282