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- Title
Comparative pharmacokinetics of enrofloxacin in healthy and Aeromonas hydrophila-infected crucian carp ( Carassius auratus gibelio).
- Authors
Fan, J.; Shan, Q.; Wang, J.; Liu, S.; Li, L.; Zheng, G.
- Abstract
The comparative pharmacokinetics of enrofloxacin ( ENR) and its metabolite ciprofloxacin ( CIP) were investigated in healthy and Aeromonas hydrophila-infected crucian carp after a single oral (p.o.) administration at a dose of 10 mg/kg at 25 °C. The plasma concentrations of ENR and of CIP were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR concentrations by noncompartmental modeling. In healthy fish, the elimination half-life ( T1/2 λz), maximum plasma concentration ( Cmax), time to peak ( Tmax), and area under the concentration-time curve ( AUC) values were 64.66 h, 3.55 μg/ mL, 0.5 h, and 163.04 μg·h/ mL, respectively. In infected carp, by contrast, the corresponding values were 73.70 h, 2.66 μg/ mL, 0.75 h, and 137.43 μg·h/ mL, and the absorption and elimination of ENR were slower following oral administration. Very low levels of CIP were detected, which indicates a low extent of deethylation of ENR in crucian carp.
- Subjects
FLUOROQUINOLONES; CRUCIAN carp; AEROMONAS hydrophila; AEROMONAS diseases; INFECTIONS in fish; DISEASES; FISHES
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2017, Vol 40, Issue 5, p580
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/jvp.12392