We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression of CD45R0 (UCHL1) by CD4<sup>+</sup> and CD8<sup>+</sup> T cells as a sign of <em>in vivo</em> activation in infectious mononucleosis.
- Authors
Miyawaki, T.; Kasahara, Y.; Kanegane, H.; Ohta, K.; Yokoi, T.; Yachie, A.; Taniguchi, N.
- Abstract
CD45R0 (UCHL1), a member of leucocyte common antigen family, is expressed largely on previously activated or memory T cells. We examined CD45R0 expression of T cell subpopulations in patients with Epstein-Barr virus (EBV) induced infectious mononucleosis (IMN) as a sign of in vivo activation. Consistent with the notion that activated CD8+ T cells expand in acute IMN, the majority of CD8+ T cells in patients with acute IMN expressed CD45R0 to the similar extent to HLA-DR expression. Most CD4+ T cells in these patients also demonstrated marked expression of CD45R0 as well as HLA-DR antigens, compared with age-matched controls. Expression of CD45R0 by CD4+ T cells in patients with acute IMN was more notable than their HLA-DR expression. While predominant CD8+ T cells resulted in decreased percentages of CD4+ T cells, CD4+ T cells expressing CD45R0 were shown to be significantly elevated in absolute number. The results suggest that both CD4+ and CD8+ T cells may be activated by stimulation with EBV infection. The appearance of two T cell subpopulations expressing CD45R0 in acute IMN implies their immunoregulatory roles in the control of EBV-infected cells.
- Subjects
MONONUCLEOSIS; GENE expression; T cells; LEUCOCYTES; EPSTEIN-Barr virus diseases; ENZYME activation
- Publication
Clinical & Experimental Immunology, 1991, Vol 83, Issue 3, p447
- ISSN
0009-9104
- Publication type
Article