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- Title
Occurrence of antibodies to single-stranded DNA in ANA negative patients.
- Authors
Wasicek, C. A.; Maddison, P. J.; Reichlin, M.
- Abstract
Five patients with clinical features of a connective tissue disease most suggestive of systemic lupus erythematosus were found to have a negative ANA by conventional screening at 1/20 dilution on mouse liver. However, significant titres of antibodies to single-stranded DNA were detected using a double antibody radioimmunoassay. Thus, certain patients have antibodies to DNA restricted to single-stranded determinants as detected by radioimmunoassay with single-stranded DNA as antigen and a negative ANA test.
- Subjects
LUPUS erythematosus; IMMUNOGLOBULINS; DNA; MEDICAL screening; RADIOIMMUNOASSAY; CONNECTIVE tissues
- Publication
Clinical & Experimental Immunology, 1979, Vol 37, Issue 2, p190
- ISSN
0009-9104
- Publication type
Article