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- Title
Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study.
- Authors
Nowak, Jan; Wojsyk-Banaszak, Irena; Mądry, Edyta; Wykrętowicz, Andrzej; Krzyżanowska, Patrycja; Drzymała-Czyż, Sławomira; Nowicka, Agata; Pogorzelski, Andrzej; Sapiejka, Ewa; Skorupa, Wojciech; Szczepanik, Mariusz; Lisowska, Aleksandra; Walkowiak, Jaroslaw
- Abstract
Purpose: As life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed to: compare their concentrations in clinically stable CF patients and healthy subjects (HS) and verify whether they independently correlate with CF characteristics. Methods: Serum sVCAM-1 and sP-selectin levels were measured using ELISA. CF was characterized using: forced expiratory volume in 1 s, exocrine pancreatic and CF-related liver disease status, Pseudomonas aeruginosa colonization, serum high-sensitivity C-reactive protein, and body mass index (BMI). CFTR genotypes were classified as severe (classes I and II) or other. Results: 108 CF patients and 51 healthy subjects volunteered for the study. In the CF group BMI was lower (median [IQR]: 20.5 kg/m [18.4-22.2] vs. 21.6 kg/m [19.9-23.4], p = 0.02) and hsCRP levels were higher (3.6 mg/L [1.1-7.1] vs. 0.5 mg/dL [0.3-1.0], p < 10). While sVCAM-1 concentrations were greater in CF patients (1018 ng/mL [851-1279] vs. 861 ng/mL [806-979], p < 10), sP-selectin levels did not differ (155 ng/mL [129-188] vs. 156 ng/mL [144-177], p = 0.48). None of the multivariable regression models was valid for the prediction of sVCAM-1 and sP-selectin in CF. Conclusions: We found higher sVCAM-1 concentrations in CF patients than in healthy subjects, which were not explained by CF characteristics. Further research is required to check whether sVCAM-1 is a marker of microangiopathy in CF.
- Subjects
VASCULAR cell adhesion molecule-1; SELECTINS; CYSTIC fibrosis; PUBLIC health; CROSS-sectional method
- Publication
Lung, 2017, Vol 195, Issue 4, p445
- ISSN
0341-2040
- Publication type
Article
- DOI
10.1007/s00408-017-0029-y