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- Title
The effect of biological mechanisms of melatonin on the proliferation of spermatogonial stem cells: a systematic review.
- Authors
Navid, Shadan; Saadatian, Zahra; Talebi, Ali; Toolee, Heidar; Seyedi, Saba
- Abstract
In the last decade, melatonin has gained recognition as a potent scavenger and an effective antioxidant capable of neutralizing free radicals, including reactive oxygen species. Additionally, it exhibits anti-apoptotic properties. In this review, we will examine a compilation of articles that explore the cellular signaling function of melatonin on spermatogonial stem cells (SSCs) and adjacent cells such as Sertoli and Leydig cells. These cells play a crucial role in the proliferation of SSCs both in vitro and in vivo. In this review, we analyze the function of melatonin in the proliferation of SSCs from other aspects. For this purpose, we examine the articles based on the presence of melatonin on SSCs in four groups: As a supplement in SSCs medium culture, SSCs three-dimensional culture system, SSCs freezing medium, and as a therapeutic factor in vivo. Mechanisms of growth and proliferation of SSCs were considered. The purpose of this study is to investigate the potential effects of melatonin as a powerful antioxidant or growth stimulant for SSCs, both in vivo and in vitro.
- Subjects
STEM cells; CELL proliferation; SERTOLI cells; LEYDIG cells; MELATONIN; CELL culture
- Publication
Anatomy & Cell Biology, 2024, Vol 57, Issue 2, p163
- ISSN
2093-3665
- Publication type
Article
- DOI
10.5115/acb.23.256