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- Title
IL-15 sustains IL-7R-independent ILC2 and ILC3 development.
- Authors
Robinette, Michelle L.; Bando, Jennifer K.; Song, Wilbur; Ulland, Tyler K.; Gilfillan, Susan; Colonna, Marco
- Abstract
The signals that maintain tissue-resident innate lymphoid cells (ILC) in different microenvironments are incompletely understood. Here we show that IL-7 receptor (IL-7R) is not strictly required for the development of any ILC subset, as residual cells persist in the small intestinal lamina propria (siLP) of adult and neonatal Il7ra−/− mice. Il7ra−/− ILC2 primarily express an ST2− phenotype, but are not inflammatory ILC2. CCR6+ ILC3, which express higher Bcl-2 than other ILC3, are the most abundant subset in Il7ra−/− siLP. All ILC subsets are functionally competent in vitro, and are sufficient to provide enhanced protection to infection with C. rodentium. IL-15 equally sustains wild-type and Il7ra−/− ILC survival in vitro and compensates for IL-7R deficiency, as residual ILCs are depleted in mice lacking both molecules. Collectively, these data demonstrate that siLP ILCs are not completely IL-7R dependent, but can persist partially through IL-15 signalling.
- Publication
Nature Communications, 2017, Vol 8, Issue 3, p14601
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/ncomms14601